2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

Related Products

PDF 32.36 MB

Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-124176
    L-6355 85642-08-6 98%
    L-6355 is an Amiodarone (HY-14187) related compound, which inhibits Ca2+/calmodulin activated cyclic nucleotide phosphodiesterase with an IC50 value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent.
    L-6355
  • HY-124363
    5-cis Carbaprostacyclin 69609-77-4 98%
    5-cis Carbaprostacyclin is a stable analog of PGI2 based on Carbaprostacyclin (HY-112322). Carbacyclin is a PGI2 receptor agonist and vasodilator that activates PPARδ. 5-cis Carbaprostacyclin induces relaxation of pulmonary vascular tone.
    5-cis Carbaprostacyclin
  • HY-124371
    Amentoflavone hexaacetate 17482-37-0 98%
    Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects.
    Amentoflavone hexaacetate
  • HY-124413
    Otosenine 16958-29-5 98%
    Otosenine is a natural pyrrolizidine alkaloid. Otosenine can be isolated from the aerial parts of the golden ragwort, Senecio aureus. Otosenine has spasmolytic and hypotensive properties.
    Otosenine
  • HY-124428
    ASP6537 524699-72-7 98%
    ASP6537 is a potent and selective rhCOX-1 inhibitor with an IC50 of 0.703 nM. ASP6537 has the potential for cardiovascular disease research.
    ASP6537
  • HY-124687
    ROMK-IN-32 1914944-54-9 98%
    ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC50 of 35 nM. ROMK-IN-32 also inhibits hERG with an IC50 of 22 μM.
    ROMK-IN-32
  • HY-124887
    L 651142 99046-40-9 98%
    L 651142 is a weak platelet activating factor (PAF) receptor antagonist. L 651142 inhibits the binding of [3H]PAF to rabbit platelet, human platelet or human lung membranes with Kis of 0.839 μM, 1.82 μM, 3.64 μM, respectively.
    L 651142
  • HY-124905
    MCI-176 103315-31-7 98%
    MCI-176 is a calcium antagonist. MCI-176 competitively inhibits calcium-induced constriction of coronary arteries.
    MCI-176
  • HY-125061
    Hydroxythiohomosildenafil 479073-82-0 98%
    Hydroxythiohomosildenafil is a Sildenafil (HY-15025) class compound that can be used to study erectile dysfunction.
    Hydroxythiohomosildenafil
  • HY-125123
    Euchrestaflavanone A 80510-05-0 98%
    Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis.
    Euchrestaflavanone A
  • HY-12515B
    (S)-Nicardipine 76093-36-2 99.25%
    (S)-Nicardipine ((S)-YC-93 free base) is the less active S enantiomer of Nicardipine. Nicardipine is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
    (S)-Nicardipine
  • HY-12515C
    (R)-Nicardipine 76093-35-1 99.64%
    (R)-Nicardipine ((R)-YC-93 free base) is the less active R enantiomer of Nicardipine. Nicardipine (YC-93) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
    (R)-Nicardipine
  • HY-125324
    Squalestatin 3 142505-92-8 98%
    Squalestatin 3 is a secondary metabolite, which can be isolated from Phoma. Squalestatin 3 is an inhibitor for squalene synthase with an IC50 of 6 nM.
    Squalestatin 3
  • HY-12533B
    Disopyramide hydrochloride 54687-36-4 98%
    Disopyramide hydrochloride is a class IA antiarrhythmic agent with efficacy in ventricular and atrial arrhythmias. Disopyramide hydrochloride blocks the fast inward sodium current of cardiac muscle and prolongs the duration of cardiac action potentials. Disopyramide hydrochloride inhibits HERG encoded potassium channels. Disopyramide hydrochloride also exhibits complex protein binding, and has a potent negative inotropic action.
    Disopyramide hydrochloride
  • HY-125341
    Microginin 527 1135249-50-1 98%
    Microginin 527 is a linear cyanobacterial peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity. Microginin 527 also exhibits inhibitory effects on protein phosphatases and leucine aminopeptidase. With an IC50 value of 31 μM, Microginin 527 is the most active component in this class of compounds.
    Microginin 527
  • HY-125386
    SQ 32056 139113-49-8 98%
    SQ 32056 is a cathepsin E inhibitor. SQ 32056 can block the pressor response to endothelin.
    SQ 32056
  • HY-125475
    Rivipansel 927881-99-0 98%
    Rivipansel (GMI-1070) is a potent E-selectin antagonist. Rivipansel prevents interaction between leukocytes and vascular endothelium. Rivipansel has the potential for the research of sickle cell vaso-occlusive crisis.
    Rivipansel
  • HY-125528
    Ro 09-1679 141426-89-3 98%
    Ro 09-1679 is a thrombin inhibitor, with an IC50 of 33.6 μM. Ro 09-1679 inhibits the enzyme activities, with IC50 values of 3.3, 0.04 and 0.0346 μM for factor Xa, trypsin and papain, respectively.
    Ro 09-1679
  • HY-125554
    KDdiA-PC 439904-34-4 98%
    KDdiA-PC is one of the most potent CD36 ligands in oxidized LDL (oxLDL).
    KDdiA-PC
  • HY-125626
    8-iso-15-keto Prostaglandin F2α 191919-01-4 98%
    8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a partial agonist for Thromboxane receptor (TP), which exhibits a vasoconstrictor efficacy with a pD2 of 5.8. 8-iso-15-keto Prostaglandin F2α mediates a weak relaxation of rats aorta rings at high concentration.
    8-iso-15-keto Prostaglandin F2α
Cat. No. Product Name / Synonyms Application Reactivity